Translation Control Therapeutics platform

Translation Control Platform
We purified and fluorescently labeled all 46 types of human tRNA
Using FRET signals from signature tRNA pair(s) of the target protein, we visualize and monitor its translation
Using all 46 tRNA pairs together, we can monitor the cell’s complete protein translation activity
Using the signature pairs for its group of proteins, we can visualize and monitor the translation of a pathway
With multiple proprietary assays, our technology helps in identifying the molecular targets of translation modulating drugs
Multiple secondary assays use proprietary techniques to identify non-toxic compounds that specifically control the target’s translation
State of the art machine learning algorithms analyze billions of data points to identify translation modulating compounds
Proprietary image analysis algorithms run over millions of images to select images where the “translation light” has been affected
85% of known proteins have a “signature tRNA pair” that repeats with high frequency in their sequence but is relatively rare in the background human genome
  • Discovery Platform

    Our platform combines breakthrough novel biology with proprietary analysis software that runs in a big-data cloud architecture. Compound libraries are screened in a purpose-built, high performance Translation Control Lab. Using our protein synthesis monitoring assays, we generate millions of images showing the impact of the different compounds on the translation of the target protein. Images are uploaded in real time into the project’s private cloud where they are analyzed by our proprietary bio-informatics, imaging and big data analysis algorithms to identify hit molecules that selectively control the translation of the target protein.

  • Hit validation and de-risking

    Analysis is done in several iterations by applying multiple secondary assays built around our technology. We analyze the impact of hit compounds on overall protein synthesis, eliminating compounds that are toxic, that interfere with the synthesis of many of the cell's proteins or that shut down the translation machinery itself. Additional translation selectivity assays were developed, which monitor the effect of compounds on groups of proteins of interest, or specific proteins along a pathway.

  • Hit optimization, Target deconvolution and mechanism of action

    Our platform verifies the selectivity of hit compounds and offers unique analysis capabilities that assist in optimization, target de-convolution and mechanism of action identification.

    Read more about mRNA Translation and Target ID technologies »