Translation Control Therapeutics platform
Our platform combines breakthrough novel biology with proprietary analysis software that runs in a big-data cloud architecture. Compound libraries are screened in a purpose-built, high performance Translation Control Lab. Using our protein synthesis monitoring assays, we generate millions of images showing the impact of the different compounds on the translation of the target protein. Images are uploaded in real time into the project’s private cloud where they are analyzed by our proprietary bio-informatics, imaging and big data analysis algorithms to identify hit molecules that selectively control the translation of the target protein.
Hit validation and de-risking
Analysis is done in several iterations by applying multiple secondary assays built around our technology. We analyze the impact of hit compounds on overall protein synthesis, eliminating compounds that are toxic, that interfere with the synthesis of many of the cell's proteins or that shut down the translation machinery itself. Additional translation selectivity assays were developed, which monitor the effect of compounds on groups of proteins of interest, or specific proteins along a pathway.
Hit optimization, Target deconvolution and mechanism of action
Our platform verifies the selectivity of hit compounds and offers unique analysis capabilities that assist in optimization, target de-convolution and mechanism of action identification.