Visual Biology
Neural networks that see pathways inside real cells. That’s the power of Anima’s Visual Biology approach - discovering better targets and drugs by seeing disease biology in action.
We share how and why this is possible through LightON, our industry-leading masterclass series followed by thousands of experts from academia and industry. Through LightON, you’ll explore how Visual Biology is enabled - how PathwayLight, our proprietary imaging system, captures regulatory pathways in action inside live cells, and how it works in tandem with a neural network trained on over 2 billion images to learn the differences between health and disease. Together, they power the new Visual Biology paradigm in drug discovery - one that starts from seeing pathways and leads to the discovery of causal, de-risked targets and small molecules that act through mRNA biology.
Our approach is modular, scalable, and applies across any disease area where visualising and learning real biology unlock insights that traditional imaging methods miss.
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TranscriptionWe visualize transcription sites as distinct circular spots in the nucleus, measuring their number, intensity, size, and shape.
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Splicing /
Alternative splicingWe monitor splicing variants within cells, tracking changes in their abundance and localization. -
CappingVisualizing capping reveals insights into the process's efficiency and mRNA protection from degradation.
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PolyadenylationImaging of polyadenylation patterns highlights changes in cell decisions that impact gene expression and translation efficiency.
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ModificationWe visualize changes in mRNA modifications, providing spatial and temporal information crucial for understanding impacts on the mRNA life cycle.
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Nuclear ExportOur visualization techniques allow us to detect mRNA nuclear accumulation, offering explanations for low protein synthesis levels.
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TransportWe observe the co-localization of mRNAs with the cytoskeleton, enhancing our understanding of mRNA's journey to its cellular destination.
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LocalizationAnalyzing mRNA localization in response to stimuli provides key insights into protein amount changes at the endpoint.
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Stability/DecayBy visualizing mRNA localization, we gain insights into the regulation of mRNA stability and decay rates, which vary across cell compartments.
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TranslationWe monitor translation in living cells, providing dynamic observations of this process and enabling the detection of translational regulation.