Biology resolution workflow
Target Biology Resolution
Reveal the mechanistic biology around a target and the disease network through which it acts, from perturbation to biological outcome.
Understand whether perturbing it propagates through disease biology and what separates a driver from a passenger.
What it means
Establishes the target's causal role and mechanistic biology within the disease network in the relevant cell state and context.
- Which proteins and biological outcomes are controlled by the target?
- How is it regulating the disease endpoint?
- Is it a driver or a passenger?
Input
A nominated target and its biology context.
- Target gene or protein
- Disease / cell type / state
- Perturbation type (e.g., KO, KD, inhibitor, overexpression)
- Controls and comparators
Output
A Target Biology Resolution Data Package - thousands of Visual Biology Tokens delivering mechanistic insight.
- Cell images of DNA, RNA and protein modifications, amount and localization and of biological activities
- Connectivity between disease onset signals to its endpoints
- Network pathways and nodes engaged or rewired
- Evidence to classify driver vs. passenger role
What it resolves
Validate causal role
Determine if the target drives disease biology or is a passenger.
Understand mechanism
Reveal how targets' perturbation propagates through the disease network.
Assess context dependency
Quantify how cellular state, disease, and environment shape the target's role.
Inform drug strategy
Prioritize, optimize, or deprioritize targets with confidence based on mechanistic evidence.
How it works
1. Define
Define the aim
The Agent frames the target within the disease network hypothesis and biological questions.
2. Design
Design visual biology experiments
The Agent designs massively parallel Visual Biology experiments across conditions, perturbations and time.
3. Execute
Run on the BioGPU Runtime
High-throughput automated execution of Visual Biology experiments at scale.
4. Generate Tokens
Generate Visual Biology Tokens
Every observed cellular activity event is converted into Visual Biology Tokens.
5. Resolve
Deliver the insight
The Agent analyzes the token package to resolve mechanism, context dependencies, and causal role.