Translation Control Therapeutics

The first platform for the discovery of small molecule drugs that selectively control mRNA translation
Watch Movie: Translation Control Therapeutics Platform
Cerebio
Translationlight
Brightny
Compass

Cerebio

Bioinformatics algorithms that select tRNA codon pair for a protein of interest

Cerebio identifies a unique tRNA pair that is used with high frequency during the target protein’s translation but is not frequently used by the background human proteome. 85% of known proteins have a tRNA pair with such “signal to noise” ratio of at least 20. The full repertoire of human tRNAs (46 isoacceptors) has been purified and labeled with red and green fluorescent tags using Anima’s patented technology.

85% of human proteins have a signature tRNA pair that can be selected by Cerebio
No. of genes
Max signal to noise ratio per gene

Translationlight

High content screening for mRNA translation modulators

When the selected “signature” pair is used in our screening system, a light pulse (FRET) is generated whenever the pair sits in a ribosome. With Translationlight, it is possible for the first time to visualize protein translation inside living cells. This capability allows Anima to discover compounds that control the process by either increasing or decreasing the translation of a specific mRNA in a selective manner. “Hit compounds” that decrease or increase the light emitted by the ribosomes are selected for further validation and analysis.


Brightny

Proprietary selectivity analysis utilizing cloud-based big data single cell analysis of millions of images

Brightny validates the selectivity of Translationlight’s identified compounds by eliminating global translation modulators, analyzing the compound’s activity along the mRNA life cycle, checking the effect on similar proteins and critical pathways, and comparing the compounds to RNAi.


Compass

Mechanism of action and Target ID identification

Compass is Anima’s proprietary technology for the elucidation of compounds’ mechanisms of action and molecular targets in the novel target space of mRNA translation regulation. With assays and algorithms focused on the biology of mRNA maturation, transport, localization and translation, Compass rapidly answers the key questions of when, where and how the compounds work along the mRNA life cycle and highlights their eventual molecular targets.


Ribosome accessory proteins
Epitranscriptomics (mRNA modifying proteins)
Splicing factors
Modifiers of ribosomal proteins (Kinases, methylases etc...)
tRNA abundance and control
RNA binding proteins