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mRNA LIGHTNING™ PLATFORM
BRINGING AI TO mRNA BIOLOGY
VISUALIZE AND DECODE mRNA BIOLOGY
MASSIVELY PARALLEL AUTOMATED mRNA BIOLOGY LAB
TWO BILLION mRNA BIOLOGY IMAGES
THE WORLD’S LARGEST DATASET OF mRNA BIOLOGY VISUALIZATIONS
THE mRNA IMAGE NEURAL NETWORK
TRAINED TO VISUALLY RECOGNIZE DISEASE MECHANISMS
mRNA BIOLOGY LLM AND THE LIGHTNING CO-PILOT
WITH MOAi TECHNOLOGY
ELUCIDATE MECHANISMS OF ACTION AND MOLECULAR TARGETS
PIPELINE OF 20 PROGRAMS
BIG PHARMA PARTNERSHIPS

Anima Biotech - mRNA Lightning™ Platform

Visualize and Decode

mRNA Biology

Anima Biotech is a recognized leader in small molecule mRNA drugs. Backed by our strategic collaborations with Lilly, Takeda and Abbvie, our mRNA lightning™ platform is bringing AI to mRNA biology. With our proprietary visualization technologies, we have generated over 2 billion images of the mRNA life cycle in cells and trained disease-specific image neural networks that visually recognize the mRNA regulatory pathways underlying disease mechanisms. With our tera-scale platform, we conduct millions of massively parallel automated biology experiments, screening for active molecules that revert the images of diseased cells back to a healthy phenotype. Our MOAi technology uses mRNA biology knowledge graph, LLM and the Lightning co-pilot to identify their mechanisms of actions and molecular targets. We advance a broad pipeline across therapeutic areas in immunology, oncology and neuroscience, and partner with Pharma in the discovery of mRNA drugs, targets and vaccines.

Our Pharma Partners

For partnering inquiries, please contact [email protected].

mRNA Lightning™ Applications

Our mRNA Lightning platform visualizes and decodes mRNA biology across multiple applications. In target discovery, our approach enables the identification of novel targets underlying disease biology. We then proceed to identify small molecule mRNA drugs that directly impact the disease phenotype, as they are visually modifying the images of mRNA biology in diseased cells to look like healthy ones. mRNA Lightning's unique ability to visualize mRNA biology in cells makes it a powerful platform for many additional applications in mRNA biology, such as the optimization of mRNA vaccines, siRNA, or ASO drugs.

2 Billion mRNA Biology Images

The world's largest dataset of mRNA biology visualizations

In over a decade of working across dozens of drug discovery programs in our pipeline and with partners, we have generated a vast amount of proprietary mRNA biology data that is driving our platform's applications. We use AI to analyze and process over 2 billion images of mRNA biology and leverage our mRNA knowledge graph and large language models for querying this large-scale data. Bringing AI to mRNA biology, our platform makes the decoding of complex biology possible.

mRNA Lightning™ Platform
Visualizing and Decoding mRNA biology
2 Billion mRNA biology images
mRNA biology knowledge graph
The mRNA image neural network
Identify the mRNA biology signature of disease mechanisms
2 Billion mRNA Biology images analysis
mRNA regulation
curated publications
OMICS
Cis-RNA elements
Thousands of
experimental results
Codon usage analyses

High-Content High-Throughput Platform

Our mRNA biology lab is a massively parallel, fully automated lab with robotics and high-end microscopy, incorporating our imaging and mRNA biology assays in high-content, high-throughput screening. The lab is running multiple screening lines in parallel, using screen-to-cloud architecture to process data at ultra-high speeds. Millions of mRNA biology images are uploaded to the cloud for analysis by the mRNA image network, our mRNA biology LLM, MOAi technology, and the Lightning co-pilot.

mRNA Lightning
AI Co-pilot
mRNA
Image Network
mRNA
Biology LLM
mRNA images
High content imaging
High scale automated screening
Plate tower
Robot
Compound library
Massively parallel
mRNA biology lab
Cerebio Bioinformatics algorithms that select signature tRNA pair for an mRNA of interest
TranslationLight High content screening for mRNA translation modulators
Brightny Cloud-based big data AI mRNA image analysis identifies active and selective molecules
Compass Mechanism of action and Target ID identification
Cloud Cloud-based mRNA high scale data analysis identifies active and selective mRNA biology modulators.
mRNA images 50 million mRNA images are uploaded to the cloud server for analysis
High content imaging 50 million mRNA images are uploaded to the cloud server for analysis
High scale automated screening Fully automated screen running 24/7 for 3 weeks
Plate Tower +250,000 diverse drug-like small molecules
Robot Fully automated screen running 24/7 for 3 weeks
Compound library +250,000 diverse drug-like small molecules
mRNA Lightning AI Co-pilot Throughout the discovery and MOA identification process, biologists interact with the system in a natural language
mRNA Image Network Recognizes disease-specific signatures
mRNA Biology LLM Integrates our extensive mRNA biology knowledge and actual experimental outcome
mRNA biology lab Tera-scale automation Conducts high content screening from our optimized library of mRNA modulators
HIGH CONTENT mRNA IMAGING
AI IMAGE ANALYSIS
DRUG DISCOVERY
TARGET DISCOVERY
mRNA Biology AI

mRNA Biology Pathway Visualizers

PathwayLight technology enables the visualization of dozens of mRNA regulatory pathways such as splicing, localization, modification, or decay/stability. Each of these visualizers is built as a high-content screening assay with the images acting as visual readouts of pathway biology.

  • Transcription
  • Splicing
  • Alternative splicing
  • Capping
  • Polyadenylation
  • Modification
  • Nuclear Export
  • Transport
  • Localization
  • Stability
  • Decay
  • Translation

Disease Signature

The mRNA image neural network identifies mRNA regulatory pathways that differentiate healthy and diseased cells, identifying the mRNA biology signature of a specific disease and forming the foundation for our target and drug discovery approaches.

Healthy
Diseased
mRNA Biology
Disease Pathway
mRNA Biology Disease Signature Decoded

As the leader in mRNA biology research with a platform that spans multiple applications, Anima has initiated the LightON mRNA Community, which now includes over 5,000 mRNA biology experts and enthusiasts from industry and the academy.

Our running webinar series provides free valuable educational insights, covering the applications of researching mRNA biology for target discovery, drug discovery, and optimization of mRNA vaccines and RNA-based drugs.

mRNA Biology Modulators Pipeline

Anima's wholly-owned pipeline of mRNA biology modulators is in Immunology (Lung fibrosis candidate advancing in preclinical stage), in Oncology (Solid tumors lead compounds entering preclinical stage and additional programs against Lymphoma and Neuroblastoma), in Neuroscience (Alzheimer's disease and Pain). In addition to our own pipeline, we established strategic collaborations with Pharma in partnered programs including our collaborations with Lilly, Takeda Pharmaceuticals, and Abbvie.

Indication   Target
Discovery
Optimization
Preclinical
Immunology
Lung fibrosis   1
Multiple fibrosis 2
Multiple fibrosis 3
Undisclosed abbvie logo 4
Oncology
Solid tumors   5
Solid tumors 6
Leukemia 7
Neuroblastoma   8
Solid tumors   9
Undisclosed abbvie logo 10
Undisclosed 11
Neuroscience
Alzheimer   12
Pain   13
Undisclosed 14
Undisclosed takeda logo 15
Undisclosed 16
Huntington   17
Undisclosed lilly logo 18
Undisclosed 19
Undisclosed 20
Area Indication Target
Discovery
Optimization
Preclinical
Immunology Lung fibrosis 1
Multiple fibrosis 2
Multiple fibrosis 3
Undisclosed abbvie logo 4
Oncology Solid tumors 5
Solid tumors 6
Leukemia 7
Neuroblastoma 8
Solid tumors 9
Undisclosed abbvie logo 10
Undisclosed 11
Neuroscience Alzheimer   12
Pain   13
Undisclosed   14
Undisclosed takeda logo 15
Undisclosed 16
Huntington   17
Undisclosed lilly logo 18
Undisclosed 19
Undisclosed 20

17 Scientific Collaborations

16 Peer Reviewed Publications

Coverage

News & Events

  • RNA Leaders Europe Congress 2024

    When: Mar. 13th, 2024 - Mar. 14th, 2024
    Where: Basel, Switzerland

    Anima’s Vice President of Business Development, Gal Gur, Ph.D., will participate in the upcoming congress during in two roundtable sessions, both focused on the topic of, “Target selection – lessons learned from small molecules RNA Biology,” to discuss her learnings from working on target selection in the mRNA biology space.

    Download Press Release »

  • Anima Biotech Announces Preclinical Data of Candidate in Idiopathic Pulmonary Fibrosis

    When: Feb. 7th, 2024

    Anima Biotech, the Tech.Bio leader bringing AI to mRNA biology, announced today positive preclinical data of its lung fibrosis candidate. This drug operates through a novel mRNA biology mechanism of action, opening new avenues for treating Idiopathic Pulmonary Fibrosis (IPF) patients.

    Download Press Release »

  • 6th Annual RNA-Targeted Drug Discovery and Development Summit

    When: Dec. 12th, 2023 - Dec. 14th, 2023
    Where: Boston, MA

    Anima Biotech will participate in the 6th Annual RNA-Targeted Drug Discovery and Development Summit taking place in Boston, MA from December 12-14, 2024.

    Download Press Release »

    Visit the conference website »