Translation Control Therapeutics
Lighting up a novel target space
mRNA translation

AnimaBiotech

Translation Control Therapeutics, a novel approach for the discovery of small molecules that selectively control mRNA translation as a new strategy against hard targets and undruggable proteins

Pharma Collaborations

Anima Biotech announces a strategic collaboration with Lilly for the discovery and development of translation inhibitors of several protein targets

$30 million in upfront payments, $14 million in research funding, up to $1.05 billion in milestones and low to mid single-digit tiered royalties on sales of any Lilly products resulting from the collaboration.

Anima Biotech announces strategic collaboration with Takeda to discover and develop mRNA translation modulators for Neurological diseases

Up to $120 million in upfront and preclinical research milestone payments, up to $1.1 billion in clinical and commercial milestones and tiered royalties on sales of any Takeda products resulting from the collaboration. Takeda has a time limited option to expand the collaboration subject to additional payments to Anima of up to $1.2 billion and tiered royalties.

For partnering inquiries, please contact [email protected].

Watch Movie: mRNA translation control

Small molecule drugs targeting novel proteins involved in the regulation of mRNA translation

The Selectivity of Translation Biology

Tissue
Tissue specific regulation
Cells
Normal vs. cancer cells
Pathway
Up or down regulated in pathological pathway
mRNA
Sequence and structure

Our Approach

Cells control protein translation using multiple selective mechanisms, offering novel intervention points. Modulation of translation is therefore possible with highly selective drugs.

mRNA translation modulators
A novel target space

mRNA
Biology
Ribosome accessory proteins
Epitranscriptomics (mRNA modifying proteins)
Splicing factors
Modifiers of ribosomal proteins (Kinases, methylases etc...)
tRNA abundance and control
RNA binding proteins

Selective translation modulators with novel mechanisms of action elucidated by Anima’s proprietary technologies

Translation Control Therapeutics platform

Watch Movie: Translation Control Therapeutics Platform

Our proprietary platform controls mRNA Translation Biology

See the Light of Protein Translation

Anima’s science is using fluorescently labeled tRNA pairs to generate FRET signals, light pulses emitted from the ribosomes to visualize the translation of any protein of interest and identify selective translation modulators

mRNA Translation Modulators Pipeline

Anima wholly owned pipeline programs are in Fibrosis (tissue selective Collagen I translation inhibitors), Oncology (c-Myc translation inhibitors and K-Ras translation inhibitors), Infectious diseases (RSV viral proteins translation inhibitors) and Neuroscience (Tau translation inhibitors and Repeat Associated Diseases, against translation malfunctions in multiple neurological diseases). In addition to our own pipeline, we established strategic collaborations with Pharma in partnered programs including our collaborations with Lilly and Takeda in Neuroscience.

Program
DISCOVERY
OPTIMIZATION
IND ENABLING
Lung Fibrosis
Oncology
K-Ras
Infectious Diseases
Neuroscience
Alzheimer's Disease
Tau
lilly logo targets *
Takeda logo HTT + 2 targets *

* Discovery programs against undisclosed targets

17 Scientific Collaborations

15 Peer Reviewed Publications

Coverage

News & Events

  • Undruggable Leaders Forum Europe

    When: Apr. 13th, 2021 - Apr. 14th, 2021

    Anima Biotech has been invited to present a corporate overview at the Undruggable Leaders Forum Europe. Yochi Slonim, Co-founder and Chief Executive Officer of Anima Biotech, and Iris Alroy, Ph.D., Vice President of Research and Development, will present a corporate overview during a session titled, “Novel Approach for the Discovery of Small Molecules that Selectively Control mRNA Translation as a New Strategy Against Undruggable Proteins.”

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    Visit the conference website »

  • Anima Biotech Announces Strategic Collaboration with Takeda to Discover and Develop mRNA Translation Modulators for Neurological Diseases

    When: Mar. 18th, 2021

    Anima Biotech, the leader in the discovery of small molecule drugs that selectively control mRNA translation, today announced that the company has entered into a strategic collaboration with Takeda Pharmaceutical Company Limited (“Takeda”) to discover and develop a new class of medicines for genetically-defined neurological diseases.

    Download Press Release »

  • Targeting RNA Virtual Summit

    When: Mar. 15th, 2021 - Mar. 17th, 2021

    Anima Biotech has been invited to present a corporate overview and participate in a panel discussion at the Targeting RNA Virtual Summit. Yochi Slonim, Co-founder and Chief Executive Officer of Anima Biotech, and Iris Alroy, Ph.D., Vice President of Research and Development, will present a corporate overview and Dr. Alroy will serve as an expert on a panel titled, “Approaching mRNA from different angles to target undruggable proteins.

    Download Press Release »

    Visit the conference website »