Translation Control Therapeutics
See the light of Protein Translation
New approach
New technology
New drugs

AnimaBiotech

Translation Control Therapeutics, the first platform for the discovery of small molecule drugs that specifically control mRNA translation

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Translation Control Discovery Platform

Breakthrough Biology

Cloud Architecture

Proprietary Analysis

Labeled tRNA
library
Target
translation
Global
translation
Pathway
translation
Target
Identification
Hit selection &
de-risking
Big data
algorithms
Translation
image
analysis
tRNA
Bioinformatics
Translation Control Platform
We purified and fluorescently labeled all 48 types of human tRNA
Using FRET signals from signature tRNA pair(s) of the target protein, we visualize and monitor its translation
Using all 48 tRNA pairs together, we can monitor the cell’s complete protein translation activity
Using the signature pairs for its group of proteins, we can visualize and monitor the translation of a pathway
With multiple proprietary assays, our technology helps in identifying the molecular targets of translation modulating drugs
Multiple secondary assays use proprietary techniques to identify non-toxic compounds that specifically control the target’s translation
State of the art machine learning algorithms analyze billions of data points to identify translation modulating compounds
Proprietary image analysis algorithms run over millions of images to select images where the “translation light” has been affected
85% of known proteins have a “signature tRNA pair” that repeats with high frequency in their sequence but is relatively rare in the background human genome
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A new strategy against hard and undruggable targets

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Specifically decrease or increase the production of target proteins

See the Light of Protein Translation

Translation Control Lab

Anima’s Translation Control Lab (TCL) is purpose-built for the discovery of translation modulators by integrating our proprietary technologies in biology, bioinformatics, big data image analysis and cloud software architecture

Anima Lab

PSM Assays
Screening
VPN

Cloud

Translation Data
Plate Processing
Plate Analysis
Image Analysis
PSM Image Creation
Plate Design
PSM Design
Big Data Visualisation
Bio Data Center
Big Data Analysis
• Experiment Design
• Analysis Assessment
• Bio Data Analysis
The Protein Synthesis Monitoring assay uses labeled tRNA pairs that generate FRET signals to monitor ribosome activity in selected cellular system.
PSM assay in a selected cellular system is used to screen a small molecule library of compounds towards the identification of compounds which change the PSM signal.
Unbiased scores are generated from more than 90 features extracted from images.
Images captured by Operetta® are automatically uploaded to the Cloud using proprietary plate processing software.
QA measures are executed to eliminate outliers wells and cells and to identify false positives.
State of the art image analysis algorithms extract unique PSM and additional cellular features as a feed for the big data analysis.
All images are captured by Operetta®, and the clean, calculated, PSM images is generated automatically.
FRET controls, assay controls are located at specific wells in all screens, enabling strict QA algorithms.
PSM design is based on proprietary mathematical algorithms analyzing the relevant RNA code.
Powerful visual and analytical tools enable us to view the results online from various mathematical and biological angles
All biological data and results are kept in a customized industry standard bio data center.
The analysis utilizes proprietary biological big data algorithms designed for translation control modulators discovery with high level of statistical significance.
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Product Pipeline

Our pipeline programs are in Fibrosis (Collagen type I translation inhibitors), RSV (inhibiting the production of viral proteins by host cell ribosomes), Oncology (C-Myc translation inhibitors) and Huntington’s Disease (monitoring mutant Huntingtin translation pausing).

Program
Assay Development
Hit Generation
Hit to lead
Preclinical
Collagen I - Target1 Lung Fibrosis
Collagen I - Target2 Liver Fibrosis
Collagen I - Target3 Scleroderma
RSV Viral Translation Inhibitors
C-Myc Oncology / Longevity
Huntingtin Huntington's disease
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Pharma Collaborations

Anima Biotech announces an exclusive collaboration with Lilly for the discovery and development of translation inhibitors of several protein targets

$30 million in upfront payments, $14 million in research funding, up to $1.05 billion in milestones and low to mid single-digit tiered royalties on sales of any Lilly products resulting from the collaboration.

For partnering inquiries, please contact partnering@animabiotech.com.

17 Scientific Collaborations

Duke University
Oxford University
The Scripps Research Institute
Alma Mater Studiorum Università di Bologna
Consiglio Nazionale delle Ricerche
Gutenberg University
Haifa University
Hamburg University
Jefferson University
Massachusetts General Hospital
Penn University
Tel-Aviv University
Texas University
Unist
Torino University
Western University
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14 Publications

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News & Events

  • Anima Biotech Lighting The Way In Protein Translation

    When: Aug. 1st, 2018

    "With a new partner in Eli Lilly, Anima Biotech and its disruptive technology that controls protein translation is starting to make waves as it urges the industry to see the light."

    Read the full article »

  • European HCS user group meeting

    When: May. 16th, 2019 - May. 17th, 2019
    Where: Barcelona, Spain

    Anima Biotech will participate and present at European HCS user group meeting. 

    This event provides a unique opportunity for users to appreciate the broad diversity of HCS applications; gain insights into new workflow solutions; share their experience, discuss challenges and learn about technology updates.

     

  • Anima Biotech named U.S. deal of the year winner at LifestarsTM Life Science Awards

    When: Nov. 20th, 2018

    Award recognizes the transformative potential of Anima’s $1B+ collaboration with Lilly.
    Anima Biotech, the leader in the discovery of drugs that specifically control protein translation, has been named winner of the “U.S. Deal of the Year” award at the 2018 Lifestars AwardsTMAward recognizes the transformative potential of Anima’s $1B+ collaboration with Lilly.

    Read the full press release »
    Download Press Release in English »
    See the link for the winners page and the video link »  

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